Lymphocyte depletion by continuous flow cell centrifugation in rheumatoid arthritis

Lymphocyte depletion and immunosuppression with repeated leukapheresis by continuous flow centrifugation.

Leukapheresis by continuous flow centrifugation (CFC) was studied in normal volunteers and patients with rheumatoid arthritis to determine whether this procedure. when carried out repeatedly. can cause lympocytopenia and immunosuppression similar to that produced by thoracic duct drainage. The removal of lymphocytes from blood by CFC was maximal in our hands at centrifuge speeds of 900-1 300 rp...

Blood cell separation in the dog by continuous flow centrifugation.

T HERE IS EVIDENCE that homologous granulocytes are beneficial in the treatment of bacterial infection when supplied to a granulocytopenic recipient. Control studies have not been done but Freireich et al.’ and Schwarzenberg et al.2 have demonstrated lysis of fever, and clinical improvement in granulocytopenic patients given granulocytes from donors with chronic myelocytic leukemia (CML ) . Cro...

Rheumatoid arthritis: beyond the lymphocyte.

Investigating Neutrophil-Lymphocyte Ratio as a Predictive Marker of Disease Activity in Rheumatoid Arthritis

Background and purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovitis, inflammation, and joint destruction that if not well controlled can destroy cartilage, bone, ligaments and tendons, and in some cases cause disability. The aim of this study was to evaluate the possible role of the ratio of neutrophil-lymphocyte (NLR) as an inflammatory mar...

Procurement of stem cells by continuous-flow centrifugation.

6. Peschle C, Marmont AM, Marone G, Genovesi A, Sasso G, Condorelli M: Pure red cell aplasia: Studies on an IgG serum inhibitor neutralizing erythropoietin. Br I Haematol 30:405, 1975 7. Krantz SB: Studies on red cell aplasia. III. Treatment with horse antihuman thymocyte gamma globulin. Blood 39:347, 1972 8. Marmont AM, Peschle C, Sanguineti M, Condorelli M: Pure red cell aplasia (PRCA): Respo...